2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. LIM Kinase (LIMK)
  5. LIM Kinase (LIMK) Isoform

LIM Kinase (LIMK)

 

LIM Kinase (LIMK) Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-136849
    TL13-68
    		Inhibitor 98.88%
    TL13-68 is a biotin-tagged version of SM1-71, and it can be used to research the mechanism of SM1-71.
  • HY-170781
    MDI-114215
    		Inhibitor 99.29%
    MDI-114215 (compound 85) is an allosteric LIMK1/2 dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research.
  • HY-P5455
    S3 Fragment
    		Inhibitor 98.71%
    S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)
  • HY-168908
    LIJTF500025
    		Inhibitor
    LIJTF500025, a chemical probe, is a potent and selective LIMK inhibitor, with pIC50 values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer.
  • HY-RS07663
    Limk1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Limk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-E70841
    LIMK2 Recombinant Human Active Protein Kinase
    LIM kinase 2 (LIMK2) is a serine/threonine and tyrosine kinases. LIMK2 plays a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an actin depolymerising factor. LIMK2 Recombinant Human Active Protein Kinase is a recombinant LIMK2 protein that can be used to study LIMK2-related functions.
  • HY-RS07667
    Limk2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Limk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS07666
    Limk2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Limk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-135843
    TH-263
    		Control 99.0%
    TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257.
  • HY-123345
    CRT 0105446
    		Inhibitor
    CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM.
  • HY-N8669
    Curcolonol
    		Inhibitor
    Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer.
  • HY-RS07665
    LIMK2 Human Pre-designed siRNA Set A
    		Inhibitor

    LIMK2 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-161417
    LIMK-IN-2
    		Inhibitor
    LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.
  • HY-144438
    Aurora/LIM kinase-IN-1
    		Inhibitor
    Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers.
  • HY-RS07664
    Limk1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Limk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS07662
    LIMK1 Human Pre-designed siRNA Set A
    		Inhibitor

    LIMK1 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-W070753
    LIMK1 inhibitor 2
    		Inhibitor
    LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with the IC50 of 9 μM.